| month | day | visitor | score | home | score |
|---|
| November | 3, 1999 | Spurs | 75 | Mavericks | 101 |
| November | 8, 1999 | Celtics | 118 | Spurs | 112 |
| November | 13, 1999 | Nuggets | 103 | Spurs | 89 |
| November | 16, 1999 | Spurs | 104 | Grizzlies | 123 |
| November | 17, 1999 | Spurs | 93 | Blazers | 124 |
| November | 20, 1999 | Spurs | 73 | Lakers | 98 |
| November | 21, 1999 | Spurs | 93 | Cavaliers | 97 |
| November | 22, 1999 | Warriors | 94 | Spurs | 97 |
| November | 23, 1999 | Spurs | 86 | Rockets | 102 |
| December | 2, 1999 | Heat | 110 | Spurs | 96 |
| December | 4, 1999 | Rockets | 113 | Spurs | 109 |
| December | 5, 1999 | Spurs | 76 | Wolves | 109 |
| December | 7, 1999 | Spurs | 106 | Wolves | 108 |
| December | 9, 1999 | Knicks | 77 | Spurs | 92 |
| December | 11, 1999 | Spurs | 79 | Grizzlies | 117 |
| December | 14, 1999 | Spurs | 100 | Grizzlies | 93 |
| December | 19, 1999 | Spurs | 101 | Knicks | 96 |
| December | 20, 1999 | Spurs | 97 | Sonics | 111 |
| December | 22, 1999 | Blazers | 133 | Spurs | 117 |
| December | 23, 1999 | Spurs | 96 | Bulls | 91 |
| December | 24, 1999 | Mavericks | 85 | Spurs | 98 |
| December | 26, 1999 | Bucks | 101 | Spurs | 120 |
| December | 27, 1999 | 76ers | 96 | Spurs | 99 |
| December | 28, 1999 | Nuggets | 99 | Spurs | 102 |
| December | 30, 1999 | Lakers | 103 | Spurs | 120 |
| December | 31, 1999 | Spurs | 84 | Magic | 107 |
| January | 1, 2000 | Spurs | 74 | Kings | 101 |
| January | 2, 2000 | Spurs | 101 | Rockets | 107 |
| January | 3, 2000 | Spurs | 99 | Mavericks | 92 |
| January | 4, 2000 | Sonics | 91 | Spurs | 105 |
| January | 7, 2000 | Hornets | 87 | Spurs | 112 |
| January | 11, 2000 | Mavericks | 102 | Spurs | 90 |
| January | 15, 2000 | Jazz | 94 | Spurs | 102 |
| January | 16, 2000 | Spurs | 88 | Kings | 90 |
| January | 18, 2000 | Spurs | 96 | Hornets | 84 |
| January | 22, 2000 | Wolves | 120 | Spurs | 108 |
| January | 26, 2000 | Cavaliers | 95 | Spurs | 107 |
| January | 27, 2000 | Spurs | 103 | Celtics | 120 |
| January | 30, 2000 | Raptors | 97 | Spurs | 111 |
| February | 1, 2000 | Spurs | 98 | 76ers | 109 |
| February | 4, 2000 | Jazz | 83 | Spurs | 99 |
| February | 8, 2000 | Spurs | 79 | Nuggets | 98 |
| February | 13, 2000 | Pacers | 90 | Spurs | 102 |
| February | 15, 2000 | Spurs | 95 | Jazz | 98 |
| February | 16, 2000 | Spurs | 102 | Bullets | 117 |
| February | 18, 2000 | Magic | 79 | Spurs | 94 |
| February | 19, 2000 | Spurs | 95 | Clippers | 105 |
| February | 20, 2000 | Spurs | 105 | Raptors | 97 |
| February | 21, 2000 | Spurs | 88 | Bucks | 104 |
| February | 24, 2000 | Spurs | 110 | Heat | 111 |
| February | 25, 2000 | Mavericks | 108 | Spurs | 118 |
| February | 28, 2000 | Spurs | 118 | Jazz | 91 |
| March | 4, 2000 | Nets | 112 | Spurs | 78 |
| March | 7, 2000 | Spurs | 105 | Sonics | 99 |
| March | 8, 2000 | Spurs | 76 | Pacers | 92 |
| March | 14, 2000 | Bullets | 117 | Spurs | 114 |
| March | 15, 2000 | Spurs | 88 | Lakers | 120 |
| March | 17, 2000 | Suns | 105 | Spurs | 94 |
| March | 18, 2000 | Spurs | 102 | Clippers | 117 |
| March | 19, 2000 | Spurs | 105 | Hawks | 77 |
| March | 21, 2000 | Nuggets | 85 | Spurs | 117 |
| March | 23, 2000 | Kings | 94 | Spurs | 84 |
| March | 24, 2000 | Spurs | 98 | Nuggets | 103 |
| March | 25, 2000 | Wolves | 122 | Spurs | 83 |
| March | 26, 2000 | Jazz | 84 | Spurs | 116 |
| March | 29, 2000 | Bulls | 105 | Spurs | 104 |
| March | 30, 2000 | Warriors | 109 | Spurs | 113 |
| April | 2, 2000 | Suns | 95 | Spurs | 104 |
| April | 3, 2000 | Rockets | 100 | Spurs | 105 |
| April | 4, 2000 | Spurs | 69 | Pistons | 118 |
| April | 6, 2000 | Clippers | 98 | Spurs | 94 |
| April | 7, 2000 | Spurs | 79 | Suns | 112 |
| April | 8, 2000 | Spurs | 106 | Warriors | 90 |
| April | 9, 2000 | Hawks | 85 | Spurs | 112 |
| April | 10, 2000 | Spurs | 117 | Blazers | 118 |
| April | 11, 2000 | Spurs | 111 | Nets | 108 |
| April | 15, 2000 | Spurs | 106 | Wolves | 103 |
| April | 16, 2000 | Rockets | 90 | Spurs | 99 |
| April | 18, 2000 | Pistons | 115 | Spurs | 109 |
| April | 20, 2000 | Sonics | 88 | Spurs | 101 |
| April | 21, 2000 | Grizzlies | 94 | Spurs | 106 |
| April | 23, 2000 | Grizzlies | 80 | Spurs | 102 |